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一 | 为了创造一种每分钟可以生产100多个可在体内分解的微机器人技术,大邱庆北科技学院(DGIST)机器人和机电工程系的Hongsoo Choi教授团队与韩国天主教大学首尔圣玛丽医院的Sung-Won Kim教授团队以及苏黎世联邦理工学院的Bradley J. Nelson教授团队合作。
以微创靶向精准治疗为目标,构建微型机器人的方法有很多。

二 | 其中最受欢迎的是被称为双光子聚合法的超精细3D打印工艺,它通过两个激光器相交引发合成树脂的聚合。这种技术有能力创建具有纳米级精度的结构。缺点是创建一个微型机器人需要大量的时间,因为体素,即通过3D打印实现的像素,必须连续固化。 Ranveer Singh has publicly apologised after criticism erupted over his mimicry of a pivotal scene from Rishab Shetty's Kantara: Chapter 1 during the IFFI 2025 closing ceremony in Goa. The moment drew strong reactions because Rishabh was seated in the audience, and many felt Ranveer’s imitation came across as insensitive, especially after he referred to the daivas as “ghosts.” Social media users quickly called out the act, saying it disrespected cultural beliefs shown in the film.
On Tuesday morning, Ranveer addressed the situation through a statement on his Instagram Stories. He clarified that his intention was only to appreciate Rishabh Shetty’s craft, writing, “My intention was to highlight Rishabh's incredible performance in the film. Actor to actor, I know how much it would take to perform that particular scene in the way that he did, for which he has my utmost admiration (sic).” Emphasising his respect for cultural diversity, he added, “I have always deeply respected every culture, tradition and belief in our country. If I've hurt anyone's sentiments, I sincerely apologise.”
The controversy began when Ranveer recreated Shetty’s Daiva performance from the film’s climax and praised him directly from the stage. During his bit, he said, "I watched Kantara Chapter 1 in theatres, and Rishab, it was an outstanding performance, especially when the female ghost (Chamundi daiva) enters your body - that shot was amazing." While Rishabh Shetty was seen laughing in the moment, many later pointed out that calling daivas ghosts was inaccurate and disrespectful, as they are considered forest deities.
Things escalated when additional footage surfaced showing Rishabh Shetty advising Ranveer not to mimic him, which sparked even more backlash. The moment has now opened a wider conversation about how public figures refer to culturally significant performances on major platforms. Ranveer’s apology continues to circulate online, drawing a mix of understanding and criticism. Rishabh has not issued a formal statement, and Ranveer is preparing for the release of Dhurandhar later this week.Also Read: Deepika Padukone and Ranveer Singh’s exchange over Ranveer’s Madame Tussauds statues wins hearts。此外,在双光子聚合过程中,机器人中的磁性纳米粒子可能会阻碍光路。当利用高浓度的磁性纳米粒子时,过程结果可能不均匀。为了解决目前微机器人生产技术的限制,DGIST教授Hongsoo Choi的研究团队创造了一种方法,通过将磁性纳米颗粒和可生物降解的甲基丙烯酸明胶的混合物流到微流控芯片上,以每分钟100个的高速度制造微机器人,该混合物可以通过光固化。与现有的双光子聚合方法相比,这可以使制造微型机器人的速度提高1万倍以上。然后,用这种技术生产的微型机器人与从人的鼻子中收集的人类鼻甲骨干细胞进行培养,以诱导干细胞粘附到微型机器人的表面。通过这一过程,制造了一个干细胞携带的微型机器人,包括内部的磁性纳米颗粒和附着在外表面的干细胞。当机器人内部的磁性纳米粒子对外部磁场作出反应时,机器人就会移动,并能移动到所需的位置。
在现有的干细胞疗法中,选择性的细胞输送是困难的。然而,携带干细胞的微型机器人可以通过实时控制电磁场控制系统产生的磁场而移动到所需的位置。研究小组进行了一项实验,检查携带干细胞的微型机器人是否能通过一个迷宫状的微通道到达目标点,并因此证实机器人可以移动到所需的位置。

三 | 此外,通过将携带微型机器人的干细胞与一种降解酶进行孵化,评估了微型机器人的可降解性。

四 | 孵化6小时后,微机器人完全解体,机器人内部的磁性纳米粒子被磁场控制系统产生的磁场收集。干细胞在微型机器人被解体的地方增殖。随后,干细胞被诱导分化成神经细胞,以确认正常分化;干细胞在大约21天后被分化成神经细胞。该实验验证了使用微型机器人将干细胞运送到所需位置是可能的,而且运送的干细胞可以通过表现出增殖和分化来作为一种有针对性的精确治疗剂。
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